This inhibitor of bacterial protein synthesis has a narrow spectrum of antibacterial activity. It has been used in the management of abdominal abscess caused by Bacteroides fragilis, but antibiotic-associated colitis has occurred. Which of the following drugs is being described?
**Core Concept**
The question is referring to a type of antibiotic that inhibits bacterial protein synthesis, specifically targeting bacteria with a narrow spectrum of activity. This antibiotic is used to treat certain bacterial infections, including those caused by Bacteroides fragilis, but can also cause antibiotic-associated colitis.
**Why the Correct Answer is Right**
The correct answer is likely a drug that specifically targets bacterial protein synthesis by binding to the 50S ribosomal subunit. This class of antibiotics is known for its narrow spectrum of activity, meaning it is effective against a limited range of bacterial species. The drug in question has been used to treat abdominal abscesses caused by Bacteroides fragilis, a type of anaerobic bacteria. However, its use has been associated with the development of antibiotic-associated colitis, a condition characterized by inflammation of the colon.
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is incorrect because the described antibiotic is not effective against gram-positive bacteria, which are typically susceptible to beta-lactam antibiotics.
* **Option B:** This option is incorrect because the described antibiotic is not a type of cephalosporin, which are a class of beta-lactam antibiotics that target cell wall synthesis.
* **Option C:** This option is incorrect because the described antibiotic is not a type of fluoroquinolone, which target DNA replication and transcription.
**Clinical Pearl / High-Yield Fact**
The use of antibiotics that inhibit bacterial protein synthesis can lead to the development of antibiotic-associated colitis, a condition that can be life-threatening if left untreated. This is because these antibiotics can disrupt the normal balance of gut flora, leading to overgrowth of pathogenic bacteria.
**Correct Answer:** C. Clindamycin