Protein (arrow) shown in the thin filament as seen in the illustration is:
Correct Answer: Troponin
Description: Ans. B. Troponina. Troponin, or the troponin complex, is a complex of three regulatory proteins (troponin C, troponin I and troponin T) that is integral to muscle contraction in skeletal muscle and cardiac muscle but not smooth muscle.b. Discussions of troponin often pertain to its functional characteristics and/or to its usefulness as a diagnostic marker or therapeutic target for various heart disorders in particular as a highly specific marker for myocardial infarction or heart muscle cell death.c. Troponin is attached to the protein tropomyosin and lies within the groove between actin filaments in muscle tissue. In a relaxed muscle, tropomyosin blocks the attachment site for the myosin crossbridge, thus preventing contraction.d. When the muscle cell is stimulated to contract by an action potential, calcium channels open in the sarcoplasmic membrane and release calcium into the sarcoplasm.e. Some of this calcium attaches to troponin, which causes it to change shape, exposing binding sites for myosin (active sites) on the actin filaments. Myosin's binding to actin causes crossbridge formation, and contraction of the muscle begins.a. Troponin activation. Troponin C (red) binds Ca2+, which stabilizes the activated state, where troponin I (yellow) is no longer bound to actin.b. Troponin T (blue) anchors the complex on tropomyosin.c. Troponin is found in both skeletal muscle and cardiac muscle, but the specific versions of troponin differ between types of muscle.d. The main difference is that the TnC subunit of troponin in skeletal muscle has four calcium ion-binding sites, whereas in cardiac muscle there are only three.e. Views on the actual amount of calcium that binds to troponin vary from expert to expert and source to source.
Category:
Physiology
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