**Core Concept**
The prostate gland is divided into several zones, each with distinct characteristics and functions. The zones are crucial in understanding the histopathology and clinical behavior of prostate cancer.

**Why the Correct Answer is Right**
Prostate cancer most commonly arises in the peripheral zone (PZ), which accounts for approximately 70-80% of all prostate cancers. The peripheral zone is the largest part of the gland and is located in the periphery of the prostate, surrounding the central zone. The peripheral zone is composed of glandular tissue and is the site of origin for the majority of prostate cancers. This is due to the higher concentration of glandular tissue in this zone, making it more susceptible to neoplastic transformation.

**Why Each Wrong Option is Incorrect**
**Option A:** The transition zone (TZ) is primarily involved in benign prostatic hyperplasia (BPH), a condition characterized by the enlargement of the prostate gland due to an increase in the number of stromal and glandular cells. While some prostate cancers can arise in the transition zone, it is not the primary site of origin.
**Option B:** The central zone (CZ) is a smaller part of the prostate gland, located between the transition zone and the peripheral zone. It is less commonly involved in prostate cancer compared to the peripheral zone.
**Option C:** The anterior fibromuscular stroma (AFS) is a fibromuscular tissue that makes up a small portion of the prostate gland. It is not a common site for prostate cancer occurrence.

**Clinical Pearl / High-Yield Fact**
The peripheral zone is the most common site of origin for prostate cancer, and its location is a critical factor in determining the clinical behavior and management of the disease.

**Correct Answer:** C.