Which of the following is NOT TRUE regarding PROPOFOL ?
**Core Concept**
Propofol is a widely used intravenous anesthetic agent known for its rapid onset of action and short duration of effect. It is commonly used in day care anesthesia (A) due to its favorable pharmacokinetic profile. Propofol is also known to cause airway irritation (D), which can be mitigated by administering it through a suitable vehicle.
**Why the Correct Answer is Right**
Propofol is not contraindicated in porphyria (B). In fact, propofol is considered safe in patients with porphyria, as it does not induce the cytochrome P450 enzyme system, which is often implicated in the pathogenesis of porphyrias. This is in contrast to other anesthetic agents like barbiturates and etomidate, which can exacerbate porphyria.
**Why Each Wrong Option is Incorrect**
**Option A:** Propofol is indeed used in day care anesthesia due to its rapid onset and short duration of action, making it suitable for short procedures. This is a true statement.
**Option C:** The commercial preparation of propofol does not contain egg extract. It is typically formulated with a lipid emulsion, which is a mixture of soybean oil and glycerol. This statement is false.
**Option D:** Propofol can cause airway irritation, which can lead to coughing, bronchospasm, and laryngospasm. This is a well-documented side effect of propofol administration. This statement is false.
**Clinical Pearl / High-Yield Fact**
It is essential to note that propofol can cause hypotension due to its vasodilatory effects, particularly when administered rapidly. To minimize this risk, it is recommended to administer propofol slowly and titrate the dose according to the patient's response.
β Correct Answer: B. It is contraindicated in porphyria