**Core Concept**
Dry Age-related Macular Degeneration (Dry ARMD) is a condition characterized by the accumulation of drusen in the macula, leading to progressive vision loss. Prophylaxis involves medications that prevent or slow the progression of the disease.
**Why the Correct Answer is Right**
Anti-vascular endothelial growth factor (VEGF) agents, such as ranibizumab, are used in the treatment of wet ARMD, not dry ARMD. These medications work by inhibiting the growth of new blood vessels, which contribute to vision loss in wet ARMD. However, they are not effective in preventing the progression of dry ARMD, which is characterized by the accumulation of drusen and retinal pigment epithelium (RPE) atrophy.
**Why Each Wrong Option is Incorrect**
**Option A:** Antioxidants, such as vitamins C and E, and zinc, have been shown to slow the progression of dry ARMD. They work by reducing oxidative stress and inflammation in the retina.
**Option B:** Omega-3 fatty acids, particularly docosahexaenoic acid (DHA), have anti-inflammatory properties and may help slow the progression of dry ARMD.
**Option C:** Statins, which are cholesterol-lowering medications, have been shown to have anti-inflammatory effects and may be beneficial in preventing the progression of dry ARMD.
**Clinical Pearl / High-Yield Fact**
Remember that dry ARMD is the more common form of ARMD, accounting for approximately 90% of cases, and is characterized by the accumulation of drusen and RPE atrophy.
**Correct Answer:** C.
Free Medical MCQs Β· NEET PG Β· USMLE Β· AIIMS
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