**Core Concept**
Seizures in alcohol withdrawal are a manifestation of the brain's response to the abrupt cessation of the depressant effects of alcohol, which leads to an imbalance of neurotransmitters such as GABA and glutamate. This imbalance triggers a hyperexcitable state in the brain, increasing the likelihood of seizures.

**Why the Correct Answer is Right**
The timing of seizures in alcohol withdrawal is critical, and they typically occur within 6-24 hours after the last drink. This is because the brain's adaptation to chronic alcohol exposure leads to an upregulation of glutamate receptors and a downregulation of GABA receptors, making the brain more excitable in the absence of alcohol. As the body begins to eliminate alcohol, the GABA receptors start to recover, leading to a relative excess of excitatory neurotransmission, which can cause seizures.

**Why Each Wrong Option is Incorrect**
**Option A:** 48 hours after the last drink is too late for seizures to occur in most cases, as the brain's adaptation to chronic alcohol exposure has begun to reverse.
**Option B:** Seizures can occur at any time during alcohol withdrawal, but they are most common within 6-24 hours after the last drink.
**Option C:** Seizures are more likely to occur within the first 24 hours after the last drink, as the brain's adaptation to chronic alcohol exposure is still reversing.

**Clinical Pearl / High-Yield Fact**
The timing of seizures in alcohol withdrawal is critical, and they are most common within 6-24 hours after the last drink. This is because the brain's adaptation to chronic alcohol exposure leads to an upregulation of glutamate receptors and a downregulation of GABA receptors, making the brain more excitable in the absence of alcohol.

**Correct Answer:** D. 24 hours