Prolonged muscle paralysis in a healthy individual may be caused by:

Correct Answer: Succinylcholine
Description: Pseudocholinesterase deficiency is an inherited enzyme abnormality that results in abnormally slow metabolic degradation of exogenous choline ester drugs such as succinylcholine and mivacurium. If there is a deficiency in the plasma activity of pseudocholinesterase, prolonged muscular paralysis may occur, resulting in the extended need for mechanical ventilation. A variety of pathologic conditions, physiologic alterations, and medications also can lower plasma pseudocholinesterase activity. Succinylcholine apnea may be seen suddenly in healthy individual due to deficiency of pseudocholinesterase .
Category: Anaesthesia
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