Prolonged administration of streptomycin may result in damage to the:
Correct Answer: Auditory nerve
Description: Streptomycin (antitubercular) causes vestibular damage on prolonged use.
Adverse effects
This class of drugs is notorious for their adverse effects like ototoxicity and nephrotoxicity.
About 1/5th patients given streptomycin 1 gm BD i.m. experience vestibular disturbances although auditory disturbances are less common.
Streptomycin has the lowest nephrotoxicity among aminoglycosides; probably because it is not concentrated in the renal cortex.
Reference: Essentials of Medical Pharmacology Eighth Edition KD TRIPATHI page no 94,798
Category:
Pharmacology
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