**Core Concept**
Prions are infectious proteins that cause neurodegenerative diseases such as Creutzfeldt-Jakob disease (CJD) and Bovine Spongiform Encephalopathy (BSE) in animals. Prions are unique in that they do not contain nucleic acid, making them unlike other infectious agents.

**Why the Correct Answer is Right**
Prions cause disease by inducing a conformational change in the normal prion protein (PrP^C), converting it into a misfolded form (PrP^Sc). This misfolded protein then aggregates and accumulates in the brain, leading to neuronal damage and death. The lack of nucleic acid in prions makes them resistant to heat, radiation, and disinfectants, allowing them to survive for extended periods outside of a host.

**Why Each Wrong Option is Incorrect**
* **Option A:** This option is incorrect as it does not accurately describe the mechanism of prion disease.
* **Option B:** This option is incorrect as prions do not contain nucleic acid, which is a key characteristic distinguishing them from other infectious agents.
* **Option C:** This option is incorrect as it does not accurately describe the pathogenesis of prion disease.

**Clinical Pearl / High-Yield Fact**
Prion diseases are always fatal and have a long incubation period, often years or even decades. Early diagnosis is challenging, and treatment options are limited.

**Correct Answer:** B. Prions do not contain nucleic acid.