Primary abnormality in sequence of events leading to DIC is-
Correct Answer: Uncontrolled thrombin generation
Description: The sequence of events in DIC are: activation of coagulation, thrombotic phase,consumption phase,secondary fibrinolysis. Massive tissue injury ,infections ,widespread endothelial damage stimulates widespread activation of coagulation pathway bye release of tissue factor & uncontrolled thrombin generation is the primary pathway.Reference:Harsh mohan textbook of pathology sixth edition pg no 337
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