**Core Concept**
The question is testing the knowledge of leprosy screening methods, specifically in areas with a low prevalence of the disease. Leprosy, also known as Hansen's disease, is a chronic bacterial infection caused by *Mycobacterium leprae*. Early detection and treatment are crucial to prevent disability and transmission.

**Why the Correct Answer is Right**
In areas with a low prevalence of leprosy, the most effective screening method is the **Single Lesion Survey (SLS)**. This method involves a thorough examination of skin lesions in the community, which can be a common symptom of leprosy. The SLS is particularly useful in low-prevalence areas because it allows for targeted screening of individuals with visible lesions, reducing the number of false positives and unnecessary testing. This approach is also more cost-effective and efficient than mass screening methods.

**Why Each Wrong Option is Incorrect**
**Option A:** Mass Screening with Skin Smear is generally recommended in areas with a high prevalence of leprosy (≥ 1/10,000). This approach is more suitable for detecting asymptomatic carriers and early cases, but it may not be cost-effective in low-prevalence areas.
**Option B:** Clinical Examination alone is not sufficient for screening leprosy, as the disease can be asymptomatic in its early stages. A combination of clinical examination and other methods, such as skin smear or PCR, is necessary for accurate detection.
**Option C:** Skin Smear is a diagnostic tool, not a screening method. It is used to confirm the presence of *M. leprae* in skin lesions, but it requires a clinical suspicion of leprosy to be performed.

**Clinical Pearl / High-Yield Fact**
In areas with a low prevalence of leprosy, the Single Lesion Survey (SLS) is a cost-effective and efficient screening method that targets individuals with visible skin lesions, reducing the number of false positives and unnecessary testing.

**Correct Answer:** C. Clinical Examination.