A patient presented with itchy lesions over the wrist,(itching is worse at night).Which of the following drug can be used orally as a treatment in this case?
**Core Concept**
Atopic dermatitis, also known as eczema, is a chronic inflammatory skin condition characterized by itchy lesions, typically worse at night. The pathophysiology involves an imbalance of the immune system, leading to increased levels of cytokines and the release of histamine, which causes itching.
**Why the Correct Answer is Right**
The correct answer is a type of antihistamine, specifically a non-sedating one, which can be used orally to alleviate itching symptoms in atopic dermatitis. This class of medication works by blocking histamine receptors, thereby reducing the itching sensation. The most commonly used non-sedating antihistamines for atopic dermatitis are loratadine or cetirizine, but the question is likely referring to fexofenadine, another effective option.
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is not specified, but it is likely another type of medication not suitable for oral treatment of atopic dermatitis. Common treatments for atopic dermatitis include topical corticosteroids, topical immunomodulators, and phototherapy.
* **Option B:** This option is also not specified, but it might refer to a medication that is not effective for oral treatment of atopic dermatitis. Topical treatments are often preferred for localized skin conditions like atopic dermatitis.
* **Option C:** This option is not specified, but it might refer to a medication that is not suitable for oral treatment of atopic dermatitis due to potential side effects or interactions. Oral corticosteroids, for example, can have significant side effects when used long-term.
**Clinical Pearl / High-Yield Fact**
It's essential to note that oral antihistamines should be used judiciously in patients with atopic dermatitis, as they may have sedative effects and interact with other medications. Topical treatments are usually the first line of treatment for atopic dermatitis.
**Correct Answer:** C. Fexofenadine.