## **Core Concept**
The question pertains to recurrent pregnancy loss, specifically late-term recurrent miscarriages, which are often defined as two or more consecutive pregnancy losses after 12 weeks of gestation. The etiology can be varied, including cervical insufficiency, uterine anomalies, hormonal imbalances, and autoimmune factors.
## **Why the Correct Answer is Right**
The correct answer, **D. Antiphospholipid syndrome**, is a condition that can cause recurrent pregnancy loss, including late-term losses. Antiphospholipid syndrome (APS) is characterized by the presence of antiphospholipid antibodies, which can lead to thrombosis and pregnancy complications, including recurrent miscarriages. The syndrome is known to cause pregnancy losses at various stages, including late-term, due to placental insufficiency and thrombosis.
## **Why Each Wrong Option is Incorrect**
- **Option A:** While cervical insufficiency can cause late-term pregnancy losses, it typically presents with painless cervical dilation leading to preterm birth or second-trimester loss, but it might not fully explain recurrent losses at similar gestational ages without other symptoms.
- **Option B:** Uterine anomalies can cause recurrent pregnancy loss, but they are more commonly associated with early pregnancy losses or preterm labor rather than specifically targeting late-term losses at similar gestational ages.
- **Option C:** Hormonal imbalances can contribute to pregnancy loss, but they are less commonly associated with such specific and recurrent late-term losses.
## **Clinical Pearl / High-Yield Fact**
A key point to remember is that antiphospholipid syndrome (APS) is a treatable cause of recurrent pregnancy loss. Women with APS and recurrent pregnancy loss may benefit from anticoagulation therapy, such as heparin and low-dose aspirin, which can significantly improve pregnancy outcomes.
## **Correct Answer: D. Antiphospholipid syndrome**
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