Pregnant woman is on valproate for juvenile myoclonic epilepsy. Alternative monotherapy of choice:
Correct Answer: Leviteracitam
Description: Ref: Lecture Notes: Clinical Pharmacology and Therapeutics, Gerard A. McKay, 8th edition, Page 90 and Atlas of Epilepsies, Volume 3, C. P. Panayiotopoulos et al., Page 1039Explanation:"The largest studies have confirmed sodium valproate as the first choice for generalized epilepsies such as juvenile myoclonic epilepsy (JME). hut where future pregnancy is a possibility. Ixunotrigine is an alternative. Levetiracetam is increasingly usedin such patients without the same level of evidence of safety in pregnancy. " Ref: Lecture Notes: Clinical Pharmacology and TherapeuticsMANAGEMENT OF JMEThe most effective drug in Men is Sodium Valproate.Sodium valproate monotherapy achieves control in 85% patients at 1-2 g daily.Clonazepam is tried in refractory myoclonic jerks.Levetiracetam is approved as adjunctive therapy in JME.Levetiracetam is safer in women of childbearing age and pregnancy.
Category:
Pharmacology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now