The use of the following drug during pregnancy can lead to Mobius syndrome :
**Core Concept:** Mobius syndrome is a rare congenital disorder characterized by the absence of facial muscles and bilateral hypoplasia of the facial nerves (cranial nerve VII). It is caused by developmental abnormalities during pregnancy, typically due to exposure to teratogens.
**Why the Correct Answer is Right:** Teratogens are substances that can cause birth defects by interfering with normal embryonic development. In the case of Mobius syndrome, the correct answer (D) refers to the drug thalidomide, a sedative-hypnotic drug introduced in the 1950s and 1960s. It was withdrawn from the market due to its severe teratogenic effects, including facial palsy and limb deformities. The drug caused widespread birth defects, including Mobius syndrome, when taken by pregnant women.
**Why Each Wrong Option is Incorrect:**
A. Thalidomide (D) is the correct answer because it is the drug associated with Mobius syndrome. The other options (A, B, C) are not related to the development of this syndrome.
B. This option is incorrect because it is not a teratogenic drug associated with Mobius syndrome.
C. This option is incorrect because it is not a teratogenic drug associated with Mobius syndrome.
D. This option is incorrect because it is the correct answer (D), not a different teratogenic drug causing Mobius syndrome.
**Clinical Pearl:** Teratogenic drugs should be avoided during pregnancy to prevent severe birth defects like Mobius syndrome. Healthcare professionals should educate pregnant women about potential risks and monitor their exposure to teratogens.
**Correct Answer:** D (Thalidomide)