**Core Concept**
The underlying principle in this question is the treatment of acute spinal cord injury (SCI) with high-dose methylprednisolone. This treatment is aimed at reducing inflammation and improving neurological outcomes in patients with acute SCI. The American Association of Neurological Surgeons (AANS) and the Joint Section on Disorders of the Spine and Peripheral Nerves recommend the use of high-dose methylprednisolone for acute SCI.

**Why the Correct Answer is Right**
High-dose methylprednisolone is given in a bolus dose of 30 mg/kg over 15 minutes, followed by an infusion of 5.4 mg/kg/hour for 23 hours. This treatment is believed to reduce the inflammatory response and prevent further damage to the spinal cord. The mechanism of action involves the inhibition of inflammatory mediators, such as prostaglandins and leukotrienes, which contribute to the secondary injury cascade in acute SCI.

**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because the dose of methylprednisolone is too low to be effective in reducing inflammation and improving neurological outcomes in acute SCI.
**Option B:** This option is incorrect because the timing of the methylprednisolone administration is not specified, and it is essential to start treatment within 8 hours of injury to be effective.
**Option C:** This option is incorrect because it suggests a different dosing regimen, which is not supported by clinical evidence.

**Clinical Pearl / High-Yield Fact**
It is essential to note that high-dose methylprednisolone should only be used in patients with acute SCI within 8 hours of injury. The treatment should be initiated promptly, and patients should be closely monitored for potential side effects.

**Correct Answer:** C. 30 mg/kg over 15 minutes, followed by 5.4 mg/kg/hour for 23 hours.