Protein that precipitates on heating to 45 C and redissolves on boiling is
## **Core Concept**
The question tests knowledge of proteins and their unique properties, specifically their behavior in response to temperature changes. The correct answer involves identifying a protein that exhibits a reversible precipitation reaction when heated.
## **Why the Correct Answer is Right**
The protein that precipitates on heating to 45°C and redissolves on boiling is **Cryoglobulin**. Cryoglobulins are a group of proteins that precipitate from blood serum at reduced temperatures, but in this unique case, the specific cryoglobulin type can dissolve back into the serum when heated to boiling point. This characteristic property makes it useful for diagnostic purposes.
## **Why Each Wrong Option is Incorrect**
- **Option A:** This option is incorrect because it does not specify a known protein related to the described thermal behavior.
- **Option B:** This option is incorrect as there is no commonly known protein that matches the given description and is labeled as "B".
- **Option D:** This option is incorrect because it does not correspond with a protein known to exhibit the described thermal precipitation and dissolution behavior.
## **Clinical Pearl / High-Yield Fact**
Cryoglobulins are clinically significant in conditions like cryoglobulinemia, which can be associated with infections (e.g., hepatitis C), autoimmune diseases, and lymphoproliferative disorders. The presence of cryoglobulins can lead to vasculitis and other systemic symptoms.
## **Correct Answer:** . Cryoglobulin