All of the following drugs can precipitate acute attack of asthma except:
**Core Concept**
The question tests the knowledge of drugs that can precipitate an acute attack of asthma by triggering bronchospasm or increasing airway responsiveness. This involves understanding the pharmacological properties of various medications and their potential effects on the respiratory system.
**Why the Correct Answer is Right**
To answer this question, one needs to consider the mechanism by which each drug can affect the airways. For example, certain beta-blockers can cause bronchoconstriction by blocking beta-2 adrenergic receptors in the lungs. Similarly, NSAIDs can precipitate asthma by inhibiting the synthesis of prostaglandins, which are protective against bronchospasm.
**Why Each Wrong Option is Incorrect**
* **Option A:** This is a correct answer, but I'll provide the correct options in the explanation. However, to follow the instructions, I'll provide the correct options in the next section and then provide the correct answer at the end.
* **Option B:** This option is incorrect because beta-2 agonists (e.g., salbutamol) are actually used to treat asthma by causing bronchodilation.
* **Option C:** This option is incorrect because anticholinergics (e.g., ipratropium bromide) are used to treat asthma by blocking muscarinic receptors and reducing bronchospasm.
* **Option D:** This option is incorrect because corticosteroids (e.g., prednisolone) are used to treat asthma by reducing inflammation and preventing bronchospasm.
**Clinical Pearl / High-Yield Fact**
Be aware that certain medications, such as beta-blockers and NSAIDs, can precipitate asthma attacks in susceptible individuals. This is especially important in patients with a history of asthma or other respiratory conditions.
**Correct Answer:** A. Beta-blockers (e.g., propranolol) can precipitate an acute attack of asthma by causing bronchoconstriction.