Postural hypotension is not seen in –
**Core Concept**
Postural hypotension, also known as orthostatic hypotension, is a sudden drop in blood pressure that occurs when a person stands up from a sitting or lying position. This condition is caused by a failure of the autonomic nervous system to regulate blood pressure and blood volume in response to changes in posture.
**Why the Correct Answer is Right**
The correct answer is likely a condition that does not involve a disruption in autonomic function or a significant impact on blood volume. One such condition is **Multiple Myeloma**. In multiple myeloma, the bone marrow produces abnormal plasma cells that can lead to bone destruction, anemia, and renal impairment. However, it does not directly affect the autonomic nervous system or cause significant orthostatic hypotension.
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is incorrect because **Diabetes Mellitus**, especially autonomic neuropathy, is a common cause of postural hypotension. Diabetic neuropathy can damage the nerves that regulate blood pressure, leading to orthostatic hypotension.
* **Option B:** This option is incorrect because **Hypothyroidism** can cause postural hypotension due to decreased vascular tone and decreased cardiac output.
* **Option C:** This option is incorrect because **Adrenal Insufficiency** can lead to postural hypotension due to decreased production of aldosterone and cortisol, which regulate blood pressure.
**Clinical Pearl / High-Yield Fact**
It's essential to remember that postural hypotension can be a symptom of various underlying conditions, and a thorough history and physical examination are necessary to identify the underlying cause.
**Correct Answer: D. Multiple Myeloma**