**Question:** A two month old infant has undergone a major surgical procedure. Regarding postoperative pain relief which one of the following is recommended:

A. **A.** Non-opioid analgesic: Paracetamol (acetaminophen)
B. **B.** Non-opioid analgesic: Ibuprofen
C. **C.** Opioid analgesic: Morphine
D. **D.** Opioid analgesic: Fentanyl

**Core Concept:** Postoperative pain management in infants involves choosing appropriate analgesics based on their pharmacological properties, age-appropriate dosing, and minimal side effects.

**Why the Correct Answer is Right:**

In infants, especially those under 6 months, the use of non-opioid analgesics is recommended due to their reduced tolerance for opioid medications and the potential for severe side effects. Paracetamol (acetaminophen) and ibuprofen are non-opioid analgesics with fewer side effects than opioids.

**Why Each Wrong Option is Incorrect:**

- **C.** Opioid analgesic: Morphine and **D.** Opioid analgesic: Fentanyl are opioid medications, which are generally contraindicated in infants due to their high risk of adverse reactions such as respiratory depression, sedation, and circulatory collapse.

**Clinical Pearl:**

When managing pain in infants, it is essential to consider their immature physiological status and the potential risks associated with opioids. Non-opioid analgesics, such as paracetamol and ibuprofen, are preferred choices for postoperative pain relief in this age group, ensuring safer and more effective treatment.