All of the following porphyria are inherited in autosomal dominant mode, EXCEPT:
**Core Concept**
Porphyrias are a group of disorders resulting from defects in the biosynthesis of heme, a vital component of hemoglobin and other hemoproteins. These disorders can be inherited in an autosomal dominant or recessive pattern, depending on the specific enzyme deficiency.
**Why the Correct Answer is Right**
Most porphyrias associated with enzyme deficiencies in the heme biosynthetic pathway exhibit an autosomal dominant pattern of inheritance. This is because a single mutated allele can lead to a significant reduction in enzyme activity, resulting in the accumulation of intermediate molecules and the manifestation of the disease. However, **Acute Intermittent Porphyria (AIP)** is an exception, as it is inherited in an autosomal dominant pattern but is caused by a mutation in the HMBS gene, which leads to a deficiency of hydroxymethylbilane synthase. Despite being autosomal dominant, AIP's inheritance pattern is unique among the porphyrias.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is not provided, but it would be incorrect if it were a porphyria known to exhibit autosomal dominant inheritance.
**Option B:** This option is not provided, but it would be incorrect if it were a porphyria known to exhibit autosomal dominant inheritance.
**Option C:** This option is not provided, but it would be incorrect if it were a porphyria known to exhibit autosomal dominant inheritance.
**Clinical Pearl / High-Yield Fact**
Acute intermittent porphyria is often associated with acute neurological symptoms, such as abdominal pain, muscle weakness, and seizures, which can be precipitated by a variety of factors, including hormonal changes, certain medications, and fasting.
**Correct Answer:** Not provided, but based on the question, it should be a porphyria that is not inherited in autosomal dominant mode.