**Core Concept**
Familial polyposis coli (FPC), also known as familial adenomatous polyposis (FAP), is a rare genetic disorder characterized by the development of numerous adenomatous polyps in the colon and rectum. It is an autosomal dominant condition, meaning a single copy of the mutated gene is sufficient to cause the disease.

**Why the Correct Answer is Right**
The correct answer is due to the association of FAP with mutations in the APC gene, which is located on the long arm of chromosome 5 (5q21-q22). The APC gene acts as a tumor suppressor, regulating cell growth and division by preventing uncontrolled cell proliferation. Mutations in the APC gene lead to the accumulation of beta-catenin, a protein that promotes cell growth and division, resulting in the formation of adenomatous polyps.

**Why Each Wrong Option is Incorrect**
**Option B:** This option is too vague, as there are many genetic disorders associated with abnormalities of chromosomes. While it is true that FAP is a chromosomal disorder, this answer does not specifically identify the chromosome involved.
**Option C:** Intestinal tuberculosis is a bacterial infection that can cause inflammation and damage to the intestinal lining, but it is not associated with the development of adenomatous polyps or familial polyposis coli.
**Option D:** Intussusception is a condition in which a part of the intestine telescopes into another part, leading to bowel obstruction. While it can cause intestinal damage and polyp formation, it is not a genetic disorder and is not associated with familial polyposis coli.

**Clinical Pearl / High-Yield Fact**
FAP is a classic example of a hereditary cancer syndrome, and patients with this condition are at high risk of developing colorectal cancer if left untreated.

✓ Correct Answer: A. Abnormality of chromosomes five.