All of the following are true about childhood polycystic kidney disease, except –
**Core Concept**
Childhood polycystic kidney disease (PKD) is a genetic disorder characterized by the growth of numerous cysts in the kidneys, leading to kidney damage and impaired function. It is associated with **autosomal dominant** or **autosomal recessive** inheritance patterns. The disease involves **cystic dilation of the renal tubules**.
**Why the Correct Answer is Right**
Since the correct answer is not provided, let's discuss the general aspects of childhood PKD. The disease often presents with **hypertension**, **hematuria**, and **proteinuria** due to the cysts' disruption of normal kidney architecture. The **PKD1** and **PKD2** genes, encoding **polycystin-1** and **polycystin-2**, are commonly mutated in this condition.
**Why Each Wrong Option is Incorrect**
**Option A:** Without the specific details of option A, we cannot determine why it is incorrect.
**Option B:** Similarly, option B's incorrectness cannot be assessed without its content.
**Option C:** Option C's details are also necessary to explain its incorrectness.
**Option D:** The same applies to option D.
**Clinical Pearl / High-Yield Fact**
A key point to remember is that childhood PKD can lead to **end-stage renal disease** (ESRD) if not properly managed. Early diagnosis and treatment are crucial to slow disease progression.
**Correct Answer:**