**Core Concept**
Copper sulphate is a toxic compound that can cause severe poisoning, primarily affecting the gastrointestinal, neurological, and hematological systems. The toxic effects of copper sulphate are due to the release of free copper ions, which can bind to sulfhydryl groups in proteins and disrupt various cellular processes.

**Why the Correct Answer is Right**
The manifestations of copper sulphate poisoning are diverse and can include gastrointestinal symptoms such as nausea, vomiting, and diarrhea, as well as neurological symptoms like tremors, seizures, and altered mental status. In severe cases, copper sulphate poisoning can lead to hemolysis, which is the breakdown of red blood cells. This is due to the binding of copper ions to hemoglobin, leading to the formation of Heinz bodies and the activation of the complement system. The correct answer is associated with hemolysis.

**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it is a manifestation of arsenic poisoning, not copper sulphate poisoning. Arsenic poisoning typically presents with gastrointestinal symptoms, neurological symptoms, and skin changes.

**Option B:** This option is incorrect because it is a manifestation of lead poisoning, not copper sulphate poisoning. Lead poisoning can cause neurological symptoms, anemia, and developmental delays in children.

**Option C:** This option is incorrect because it is a manifestation of mercury poisoning, not copper sulphate poisoning. Mercury poisoning can cause neurological symptoms, kidney damage, and tremors.

**Clinical Pearl / High-Yield Fact**
The Heinz body is a characteristic feature of copper sulphate poisoning, and it is formed due to the binding of copper ions to hemoglobin. This is an important diagnostic clue in cases of copper sulphate poisoning.

**Correct Answer:** D. Hemolysis.