**Core Concept**
Ethylene glycol poisoning is a medical emergency requiring prompt treatment to prevent serious complications, including metabolic acidosis, renal failure, and seizures. The antidote for ethylene glycol poisoning should effectively inhibit alcohol dehydrogenase, the enzyme responsible for converting ethylene glycol to its toxic metabolites.
**Why the Correct Answer is Right**
Fomepizole is a specific and effective antidote for ethylene glycol poisoning. It competitively inhibits alcohol dehydrogenase, thereby preventing the formation of toxic metabolites. This results in a decrease in the severity of symptoms and an improvement in patient outcomes. Fomepizole is preferred over ethanol as an antidote because it has a more predictable and potent effect.
**Why Each Wrong Option is Incorrect**
* **Option A:** Methyl violet is a chemical used as a dye and a stain, but it has no role in the treatment of ethylene glycol poisoning.
* **Option B:** Fluconazole is an antifungal medication and has no effect on the metabolism of ethylene glycol.
* **Option D:** Ethyl alcohol (ethanol) is sometimes used as an antidote for ethylene glycol poisoning, but it is not the preferred treatment due to its unpredictable absorption and potential for causing further intoxication. Fomepizole is a more reliable and safer option.
**Clinical Pearl / High-Yield Fact**
When treating ethylene glycol poisoning, it's essential to remember that fomepizole is the preferred antidote due to its potent and predictable inhibition of alcohol dehydrogenase. Fomepizole should be administered promptly, along with supportive care, to prevent serious complications.
**Correct Answer:** .
Free Medical MCQs Β· NEET PG Β· USMLE Β· AIIMS
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