**Core Concept**
The question is testing the ability to identify a metal poisoning that affects bone metabolism, leading to changes that can be detected through bone analysis. This requires knowledge of the pathophysiology of metal poisoning and its effects on the body.

**Why the Correct Answer is Right**
Lead poisoning (option C) is known to affect bone metabolism by inhibiting osteoblast activity and promoting osteoclast activity, leading to an increase in bone resorption. This can result in changes in bone density and structure that can be detected through analysis of bone samples. Lead accumulates in bone and can be released into the bloodstream during periods of bone resorption, making it a useful indicator of lead exposure.

**Why Each Wrong Option is Incorrect**
**Option A:** Mercury poisoning primarily affects the nervous system and kidneys, but it does not have a significant impact on bone metabolism.
**Option B:** Arsenic poisoning affects multiple organ systems, including the skin, lungs, and cardiovascular system, but it is not typically associated with changes in bone density or structure.
**Option D:** Cadmium poisoning affects the kidneys and bones, but it primarily causes damage through the accumulation of cadmium in the kidneys, leading to renal dysfunction, rather than changes in bone metabolism.

**Clinical Pearl / High-Yield Fact**
When suspecting metal poisoning, it's essential to consider the patient's occupation, hobbies, and environmental exposure, as well as their symptoms and laboratory results.

**Correct Answer: C. Lead poisoning can be detected by analysing bone.**