PNH patients will be having deficient surface proteins that normally protect the red cells from activated compliments. What are the two deficient surface proteins?
Correct Answer: CD 55 and CD 59
Description: The definitive diagnosis of PNH is based on the demonstration that a substantial propoion of the patient's red cells have an increased susceptibility to complement (C), due to the deficiency on their surface of proteins (paicularly CD59 and CD55). Reference: Harrisons Principles of Internal Medicine, 18th Edition, Page 884
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