**Core Concept**
Pneumoperitoneum resulting from colonoscopic perforation requires prompt treatment to prevent complications such as peritonitis and sepsis. The goal is to stabilize the patient, close the perforation, and prevent further bowel contamination.

**Why the Correct Answer is Right**
The treatment of choice for pneumoperitoneum due to colonoscopic perforation in a young patient is surgical intervention, specifically laparoscopic or open repair of the perforation. This approach allows for direct visualization and closure of the perforation, reducing the risk of complications. In some cases, a temporary diverting colostomy may be necessary to manage the bowel and prevent further contamination.

**Why Each Wrong Option is Incorrect**
**Option A:** Antibiotics alone are not sufficient to treat pneumoperitoneum resulting from colonoscopic perforation, as they do not address the underlying cause of the perforation.
**Option B:** Conservative management with nil per os (NPO) status and bowel rest may be considered in cases of small, asymptomatic perforations, but it is not the definitive treatment for pneumoperitoneum due to colonoscopic perforation.
**Option C:** CT-guided drainage may be used to manage complications such as abscesses or fluid collections, but it is not the primary treatment for pneumoperitoneum due to colonoscopic perforation.

**Clinical Pearl / High-Yield Fact**
In cases of colonoscopic perforation, prompt recognition and treatment are crucial to prevent complications. A high index of suspicion for perforation should be maintained during and after the procedure, and immediate surgical consultation should be sought if perforation is suspected.

**Correct Answer:** C.