Which of the following statements about Pneumococcus is false:
**Core Concept**
Pneumococcus, a type of Gram-positive bacterium, is a leading cause of community-acquired pneumonia (CAP) and other invasive infections. The bacterium's virulence is attributed to its polysaccharide capsule, which protects it from phagocytosis.
**Why the Correct Answer is Right**
The correct answer will be the statement that does not accurately describe Pneumococcus. The polysaccharide capsule of Pneumococcus is a key virulence factor, composed of various serotypes (such as type 1, 2, and 14). The capsule inhibits phagocytosis by preventing the activation of the complement system and by interfering with the binding of opsonizing antibodies. This allows the bacteria to evade the host's immune response and cause disease.
**Why Each Wrong Option is Incorrect**
* **Option A:** This statement is false because Pneumococcus is not typically resistant to beta-lactam antibiotics, which are commonly used to treat pneumococcal infections. While resistance to certain antibiotics, such as penicillin, has been reported, this is not a characteristic of Pneumococcus as a whole.
* **Option B:** This statement is not false, as Pneumococcus can cause meningitis, particularly in children and older adults.
* **Option C:** This statement is not false, as Pneumococcus is a leading cause of CAP and can cause bacteremia, which is the presence of bacteria in the blood.
**Clinical Pearl / High-Yield Fact**
It's essential to remember that Pneumococcus can cause a range of invasive infections, including pneumonia, meningitis, and bacteremia. The bacterium's polysaccharide capsule is a key virulence factor, and vaccination against Pneumococcus is an effective way to prevent invasive infections.
**Correct Answer: A. Pneumococcus is typically resistant to beta-lactam antibiotics.**