Plateau phase of cardiac cycle is due to –
**Core Concept**
The plateau phase of the cardiac cycle, also known as the plateau phase of the action potential, is a critical period during which the cardiac muscle cells (cardiomyocytes) are in a refractory state, making them resistant to further stimulation. This phase is characterized by a prolonged depolarization, which is essential for the generation of a strong contraction.
**Why the Correct Answer is Right**
The plateau phase is primarily due to the slow inward movement of calcium ions (CaΒ²βΊ) into the cardiomyocyte through the L-type calcium channels (LTCCs). This influx of calcium ions is facilitated by the dihydropyridine receptors (DHPRs) and the ryanodine receptors (RyRs), which are responsible for the release of calcium ions from the sarcoplasmic reticulum. The subsequent increase in intracellular calcium concentration triggers a series of events that ultimately lead to the contraction of the cardiac muscle.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because the plateau phase is not primarily due to the repolarization of the cardiac muscle cells. While repolarization is an essential process, it occurs after the plateau phase, not during it.
**Option B:** This option is incorrect because the plateau phase is not solely due to the autonomic nervous system's regulation of the heart rate. While the autonomic nervous system plays a crucial role in modulating heart rate, it is not directly responsible for the plateau phase.
**Clinical Pearl / High-Yield Fact**
The plateau phase of the cardiac cycle is a critical period during which the heart is most susceptible to arrhythmias, particularly ventricular tachycardia and fibrillation. This is why medications that prolong the QT interval, such as certain antipsychotics and antiarrhythmics, can increase the risk of serious cardiac arrhythmias.
**Correct Answer:** C. The slow inward movement of calcium ions through the L-type calcium channels.