A 27-year-old man presents to the clinic for evaluation of low back pain and stiffness. The discomfort started many months ago, but recently he has noticed more severe stiffness at night and new symptoms of hip pain. The pain improves in the morning after doing some “stretching” exercises. On physical examination, there is paravertebral muscle and sacroiliac joint tenderness on palpation with limited forward flexion of the lumbar spine. A 2/6 diastolic murmur is also heard at the left sternal border radiating to the apex. Plain x-rays of the spine are suggestive of sacroiliitis. Which of the following is the most likely diagnosis for the diastolic murmur?
A 27-year-old man presents to the clinic for evaluation of low back pain and stiffness. The discomfort started many months ago, but recently he has noticed more severe stiffness at night and new symptoms of hip pain. The pain improves in the morning after doing some “stretching” exercises. On physical examination, there is paravertebral muscle and sacroiliac joint tenderness on palpation with limited forward flexion of the lumbar spine. A 2/6 diastolic murmur is also heard at the left sternal border radiating to the apex. Plain x-rays of the spine are suggestive of sacroiliitis. Which of the following is the most likely diagnosis for the diastolic murmur?
π‘ Explanation
**Core Concept**
The patient's presentation with low back pain, stiffness, paravertebral muscle and sacroiliac joint tenderness, limited forward flexion of the lumbar spine, and suggestive sacroiliitis on plain x-rays is indicative of ankylosing spondylitis, a chronic inflammatory disease primarily affecting the axial skeleton. The presence of a diastolic murmur in this context suggests a cardiac complication.
**Why the Correct Answer is Right**
The diastolic murmur is likely due to aortic regurgitation (AR), a condition characterized by the backflow of blood from the aorta into the left ventricle during diastole. In patients with ankylosing spondylitis, there is an increased risk of developing AR, possibly due to the inflammation and fibrosis of the aortic root. This can lead to aortic valve incompetence, resulting in a diastolic murmur.
**Why Each Wrong Option is Incorrect**
**Option A:** Mitral regurgitation is less likely, as it would typically present with a holosystolic murmur and symptoms of pulmonary congestion, which are not mentioned in the patient's presentation.
**Option B:** Tricuspid regurgitation is also unlikely, as it would typically present with a systolic murmur and symptoms of right heart failure, which are not mentioned in the patient's presentation.
**Option C:** Pulmonic regurgitation is not a common finding in ankylosing spondylitis and would not explain the diastolic nature of the murmur.
**Clinical Pearl / High-Yield Fact**
Aortic regurgitation in patients with ankylosing spondylitis can be a sign of a more severe disease course, with increased risk of cardiac complications and mortality.
**Correct Answer:** C. Aortic regurgitation.
β Correct Answer: C. aortic insufficiency
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