A 62-year-old man has had back pain for 4 months. No abnormal findings are noted on physical examination. A CBC shows a WBC count of 3700/microliter, hemoglobin 10.3 g/dL, hematocrit 31.1%, MCV 85 fL, and platelet count 110,000/microliter. His total serum protein is 8.5 gm/dl with an albumin of 4.1 gm/dl. A chest radiograph shows no abnormalities of heart or lung fields, but there are several lucencies noted in the vertebral bodies. A sternal bone marrow aspirate is performed and yields a dark red jelly-like material in the syringe. Which of the following cell types is most likely to be numerous on microscopic examination of this aspirate?
A 62-year-old man has had back pain for 4 months. No abnormal findings are noted on physical examination. A CBC shows a WBC count of 3700/microliter, hemoglobin 10.3 g/dL, hematocrit 31.1%, MCV 85 fL, and platelet count 110,000/microliter. His total serum protein is 8.5 gm/dl with an albumin of 4.1 gm/dl. A chest radiograph shows no abnormalities of heart or lung fields, but there are several lucencies noted in the vertebral bodies. A sternal bone marrow aspirate is performed and yields a dark red jelly-like material in the syringe. Which of the following cell types is most likely to be numerous on microscopic examination of this aspirate?
π‘ Explanation
**Core Concept**
The patient's symptoms and laboratory findings suggest a diagnosis of myelophthisic anemia, characterized by bone marrow infiltration and fibrosis leading to ineffective erythropoiesis. The sternal bone marrow aspirate's jelly-like consistency and dark red coloration indicate a high cellularity and presence of a specific cell type.
**Why the Correct Answer is Right**
The jelly-like consistency of the bone marrow aspirate is consistent with a high cellularity and the presence of numerous plasma cells. Plasma cells are a type of mature B lymphocyte that plays a crucial role in producing antibodies. In this case, the infiltration of plasma cells into the bone marrow is likely responsible for the patient's anemia and back pain. The presence of lucencies in the vertebral bodies on chest radiograph suggests bone marrow infiltration and fibrosis, which is consistent with myelofibrosis.
**Why Each Wrong Option is Incorrect**
**Option A:** Megakaryocytes are a type of bone marrow cell involved in platelet production. However, the patient's platelet count is only mildly decreased, making this option less likely.
**Option B:** Erythroblasts are immature red blood cells. While the patient does have anemia, the bone marrow aspirate's dark red coloration and jelly-like consistency suggest a more mature cell type.
**Option C:** Lymphocytes are a type of immune cell, but they are not typically associated with the jelly-like consistency of the bone marrow aspirate.
**Option D:** Monocytes are a type of white blood cell, but they are not typically associated with the bone marrow infiltration and fibrosis seen in this patient.
**Clinical Pearl / High-Yield Fact**
Myelophthisic anemia can be caused by a variety of underlying conditions, including myelofibrosis, lymphoma, and metastatic cancer. The presence of lucencies in the vertebral bodies on chest radiograph can be a clue to the diagnosis of myelophthisic anemia.
**Correct Answer:** C.
β Correct Answer: D. Plasma cells
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