Anti phospholipid syndrome (APS) is associated with all of the following except:
**Core Concept**
Anti-phospholipid syndrome (APS) is a systemic autoimmune disorder characterized by the presence of anti-phospholipid antibodies, which are directed against phospholipid-binding proteins. This condition is associated with a hypercoagulable state, leading to thrombosis and other clinical manifestations.
**Why the Correct Answer is Right**
APS is a complex condition involving the interplay of multiple factors, including endothelial dysfunction, platelet activation, and the presence of anti-phospholipid antibodies. These antibodies can bind to and activate factor Xa, leading to the formation of thrombi. The clinical manifestations of APS include thrombosis, recurrent fetal loss, and thrombocytopenia.
**Why Each Wrong Option is Incorrect**
**Option A:** While APS is often associated with systemic lupus erythematosus (SLE), it can also occur in isolation or in association with other autoimmune disorders. Therefore, this option is incorrect.
**Option B:** Thrombocytopenia is a common feature of APS, often presenting as isolated thrombocytopenia or as part of a broader clinical picture. This option is incorrect.
**Option C:** This option is correct. While APS is often associated with arterial and venous thrombosis, it is not typically associated with a bleeding diathesis.
**Clinical Pearl / High-Yield Fact**
APS is a treatable condition, and early recognition and management are crucial to preventing morbidity and mortality. The presence of anti-phospholipid antibodies should prompt a thorough evaluation for thrombosis and other clinical manifestations.
**Correct Answer: C.**