In the metabolism of alcohol, high doses of aspirin & phenytoin, mechanism is ?
**Core Concept**
The metabolism of alcohol involves the enzyme alcohol dehydrogenase (ADH), which converts ethanol into acetaldehyde. However, high doses of certain drugs can inhibit this process, leading to increased blood alcohol levels and potentially toxic effects.
**Why the Correct Answer is Right**
The correct answer involves the inhibition of alcohol dehydrogenase (ADH) by high doses of aspirin and phenytoin. Aspirin and phenytoin are known to inhibit the activity of ADH, leading to a decrease in the conversion of ethanol to acetaldehyde. This results in higher blood alcohol levels, which can cause adverse effects such as drowsiness, confusion, and even coma.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it does not accurately describe the mechanism of action of aspirin and phenytoin on alcohol metabolism.
**Option B:** This option is incorrect because it refers to a different enzyme, cytochrome P450, which is involved in the metabolism of various drugs, but not directly related to the metabolism of alcohol.
**Option C:** This option is incorrect because it mentions the inhibition of acetaldehyde dehydrogenase, which is a different enzyme involved in the further metabolism of acetaldehyde to acetate.
**Clinical Pearl / High-Yield Fact**
When prescribing aspirin or phenytoin to patients who consume alcohol, it is essential to monitor their blood alcohol levels closely, as these medications can lead to increased toxicity.
**Correct Answer: C. Inhibition of alcohol dehydrogenase by aspirin & phenytoin.**