Dawn phenomenon refers to: March 2013
**Core Concept**
The dawn phenomenon is a physiological response that occurs in the early morning hours, typically between 2-8 am, where there is an increase in glucose production and a decrease in insulin sensitivity, leading to elevated blood glucose levels.
**Why the Correct Answer is Right**
This phenomenon is primarily driven by the release of counter-regulatory hormones such as growth hormone, cortisol, and glucagon, which stimulate the liver to release stored glucose (glycogen) into the bloodstream. Additionally, the decrease in insulin sensitivity during this period further contributes to the increase in blood glucose levels. As a result, individuals with diabetes may experience early morning hyperglycemia.
**Why Each Wrong Option is Incorrect**
**Option B:** Early morning hypoglycemia is incorrect because the dawn phenomenon is characterized by an increase in glucose production, not a decrease. Hypoglycemia is typically seen in the context of excessive insulin administration or impaired glucose counter-regulation.
**Option C:** Hypoglycemia followed by hyperglycemia is incorrect because the dawn phenomenon is a gradual increase in glucose levels over several hours, not a biphasic response. Furthermore, the typical sequence is an increase in glucose followed by a decrease, not the reverse.
**Option D:** High insulin levels is incorrect because the dawn phenomenon is associated with decreased insulin sensitivity, not an increase in insulin levels. The body's response to the counter-regulatory hormones is to increase glucose production, not insulin secretion.
**Clinical Pearl / High-Yield Fact**
The dawn phenomenon is a common cause of early morning hyperglycemia in individuals with diabetes, and its management often involves adjusting the timing and dosage of insulin or oral hypoglycemic agents to mitigate this effect.
**β Correct Answer: A. Early morning hyperglycemia**