**Core Concept**
Phaeochromocytoma is a rare, catecholamine-secreting tumor of the adrenal medulla. The hallmark features of this condition are episodic releases of catecholamines (adrenaline and noradrenaline), leading to characteristic clinical manifestations.
**Why the Correct Answer is Right**
Wheezing is not a typical feature of phaeochromocytoma. The correct manifestations are often related to the effects of excessive catecholamine release on the cardiovascular and nervous systems. The episodic release of catecholamines can cause sudden, severe hypertension (hypeensive paroxysm), headaches, and orthostatic hypotension due to the sudden drop in blood pressure upon standing. Wheezing, on the other hand, is more commonly associated with asthma or chronic obstructive pulmonary disease (COPD), conditions that involve airway constriction or inflammation.
**Why Each Wrong Option is Incorrect**
**Option A:** Hypeensive paroxysm is a classic feature of phaeochromocytoma, resulting from the episodic release of catecholamines.
**Option B:** Headache is another common symptom of phaeochromocytoma, often caused by the sudden, severe hypertension.
**Option C:** Orthostatic hypotension is a characteristic feature of phaeochromocytoma, resulting from the sudden drop in blood pressure upon standing due to excessive catecholamine release.
**Clinical Pearl / High-Yield Fact**
Phaeochromocytoma is often referred to as the "10% tumor" because it accounts for approximately 10% of cases of hypertension that are resistant to treatment. Remember that wheezing is not a typical feature of phaeochromocytoma, and other symptoms should be prioritized in the differential diagnosis.
**β Correct Answer: D. Wheezing**
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