**Core Concept**
The Peussis vaccine, also known as the acellular pertussis vaccine, is a commonly administered vaccine in pediatric practice to prevent pertussis (whooping cough). Like all vaccines, it can cause side effects, which are generally mild and self-limiting.

**Why the Correct Answer is Right**
The Peussis vaccine side effects are primarily localized to the injection site and can include local pain, redness, and swelling. Systemically, the vaccine can cause fever, which is often accompanied by excessive crying in infants. This excessive crying, also known as irritability, is a common manifestation of pain and discomfort in infants. The mechanism behind this is not fully understood, but it is thought to be related to the baby's inability to articulate their pain.

**Why Each Wrong Option is Incorrect**
**Option A:** Local pain is indeed a common side effect of the Peussis vaccine, but it is not the only one. Thus, this option is incomplete.
**Option B:** Excessive cry is a manifestation of the systemic side effects of the vaccine, but it is not the only symptom. Therefore, this option is also incomplete.
**Option C:** Fever is a systemic side effect of the vaccine, but it is not the only one. This option is also incomplete.

**Clinical Pearl / High-Yield Fact**
It is essential for pediatricians to be aware of the potential side effects of vaccines, including the Peussis vaccine, to manage and reassure parents accordingly. A simple explanation of the expected side effects can go a long way in alleviating parental anxiety and promoting vaccine acceptance.

**✓ Correct Answer: D. All of above**