Medical MCQ-Person had severe pruritis while taking hot shower and presents with deep vein thrombosis. He also had JAK 2 mutation and hypeension. Which of the following is the most likely diagnosis of this patient?

Person had severe pruritis while taking hot shower and presents with deep vein thrombosis. He also had JAK 2 mutation and hypeension. Which of the following is the most likely diagnosis of this patient?

Myelofibrosis

Polycythemia Vera

CML

AML

Question Category:

Pathology

Correct Answer:

Polycythemia Vera

Description:

The presence of JAK2 mutation indicates that it is an example of Myeloproliferative disorder. Polycythemia vera is strongly associated with activating point mutations in the tyrosine kinase JAK2. Clinical features: Headache, dizziness, hypeension,Intense pruritus and peptic ulceration possibly resulting from the release of histamine from basophils. Hot showers ( AQUAGENIC PRURITUS ) will result in degranulation of the basophils thus releasing histamines.

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