**Core Concept**
Persistent pupillary membrane (PPM) is an embryological anomaly characterized by the incomplete regression of the pupillary membrane, a structure that normally covers the pupil during fetal development. It is a type of congenital anomaly that affects the iris.
**Why the Correct Answer is Right**
PPM originates from the persistent remnant of the pupillary membrane, which is a layer of cells and fibers that spans the pupil. Normally, this membrane atrophies and disappears by the end of fetal development. However, in cases of PPM, the remnants of this membrane fail to regress, leading to a fibrovascular membrane that spans the pupil. This membrane can be attached to the iris stroma or the lens, causing various degrees of pupillary obstruction.
**Why Each Wrong Option is Incorrect**
**Option A:** This is incorrect because PPM does not originate from the anterior lens capsule.
**Option B:** This is incorrect because PPM does not originate from the posterior lens capsule.
**Option C:** This is incorrect because PPM does not originate from the vitreous gel.
**Clinical Pearl / High-Yield Fact**
PPM can cause pupillary obstruction, glare, and vision disturbances in some cases. It is often asymptomatic, but it can be associated with other congenital anomalies, such as colobomas or aniridia.
**Correct Answer: D. Remnant of pupillary membrane.**
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