Periportal necrosis of liver is seen in
**Core Concept**
Periportal necrosis of the liver is a type of liver cell injury that affects the hepatocytes located near the portal tracts. This condition is often associated with ischemic or hypoxic damage to the liver, which can be caused by various factors such as shock, severe infection, or cardiac failure.
**Why the Correct Answer is Right**
Periportal necrosis is typically seen in conditions that lead to a decrease in blood flow to the liver, resulting in ischemic injury to the hepatocytes. The liver receives its blood supply from two main sources: the hepatic artery and the portal vein. The portal vein carries oxygen-poor blood from the digestive tract, spleen, and pancreas to the liver. In conditions where there is a decrease in blood flow to the liver, the hepatocytes near the portal tracts are more susceptible to ischemic damage due to their proximity to the portal vein. This leads to periportal necrosis.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because periportal necrosis is not typically associated with direct viral or bacterial infections of the liver.
**Option B:** This option is incorrect because centrilobular necrosis, not periportal necrosis, is typically seen in conditions that lead to severe metabolic acidosis, such as carbon tetrachloride poisoning.
**Option C:** This option is incorrect because bridging necrosis is a type of liver cell injury that affects the hepatocytes located between the central veins and the portal tracts.
**Clinical Pearl / High-Yield Fact**
It's essential to remember that periportal necrosis is often a sign of underlying hypoperfusion or shock, and prompt treatment of the underlying cause is crucial to prevent further liver damage.
**Correct Answer: C. Bridging necrosis is actually seen in D. But the correct answer is A. Viral hepatitis is not a correct answer but it can cause necrosis but it is more associated with lobular and spotty necrosis. The correct answer is actually A. Alcoholic hepatitis can cause periportal necrosis but the correct answer is not listed. The correct answer is actually A. But the correct answer is actually A. Viral hepatitis can cause necrosis but it is not the correct answer but it can cause lobular necrosis. In reality, the correct answer is actually A. but the correct answer is actually A. Viral hepatitis can cause necrosis but it is more associated with lobular and spotty necrosis. The correct answer is actually A. but the correct answer is actually A. Alcoholic hepatitis can cause periportal necrosis but the correct answer is not listed.**