Periportal fatty infiltration of the liver is seen with-
**Core Concept**
Periportal fatty infiltration of the liver refers to the accumulation of fat in the periportal regions of the liver lobules, which is a characteristic finding in certain liver conditions. This pattern of fatty change is often associated with **insulin resistance** and **hepatic steatosis**. The underlying mechanism involves impaired insulin signaling and increased lipid accumulation in hepatocytes.
**Why the Correct Answer is Right**
The correct answer is associated with conditions that lead to insulin resistance and hepatic steatosis, such as **non-alcoholic fatty liver disease (NAFLD)**. In NAFLD, the liver's ability to regulate lipid metabolism is impaired, leading to the accumulation of fat in hepatocytes, particularly in the periportal regions. This is often linked to **obesity**, **type 2 diabetes**, and **metabolic syndrome**.
**Why Each Wrong Option is Incorrect**
**Option A:** is incorrect because it is not directly related to periportal fatty infiltration.
**Option B:** is incorrect as it is more commonly associated with a different pattern of liver injury.
**Option C:** is incorrect because it is not a recognized cause of periportal fatty liver.
**Clinical Pearl / High-Yield Fact**
Periportal fatty infiltration is a significant finding in liver pathology, as it can progress to more severe conditions such as **steatohepatitis** and **cirrhosis**. Recognizing the association between periportal fatty change and underlying metabolic disorders is crucial for early diagnosis and management.
**Correct Answer:** D. Low-grade non-alcoholic fatty liver disease