All are true about neutrophil in peripheral smear examination, EXCEPT:
**Core Concept**
A peripheral smear examination is a crucial diagnostic tool in hematology that involves analyzing a blood sample to detect various cellular abnormalities, including those related to neutrophils. Neutrophils are a type of white blood cell that play a key role in the body's defense against infections. The examination of neutrophils in a peripheral smear can reveal information about their morphology, function, and behavior.
**Why the Correct Answer is Right**
In a peripheral smear examination, a normal neutrophil typically has a multilobed nucleus with 3-5 lobes, also known as a multilobulated nucleus. This characteristic is a result of the process of nuclear segmentation during neutrophil maturation. Additionally, neutrophils often have a large, dark-staining cytoplasm with 2-5 azurophilic granules and 10-20 specific granules. These granules are responsible for the release of enzymes and antimicrobial peptides that help to eliminate pathogens.
**Why Each Wrong Option is Incorrect**
**Option A:**
*Option A is incorrect because it does not specify the correct characteristic of a normal neutrophil. While it is true that neutrophils can have a bilobed nucleus, this is not the only characteristic that defines a normal neutrophil.*
**Option B:**
*Option B is incorrect because it is a true statement about neutrophils. Neutrophils do indeed have a multilobulated nucleus, which is a key feature of their morphology.*
**Option C:**
*Option C is incorrect because it is a true statement about neutrophils. Neutrophils do indeed have a large, dark-staining cytoplasm with azurophilic and specific granules, which are essential for their function.*
**Option D:**
*Option D is incorrect because it is a true statement about neutrophils. Neutrophils do indeed have a multilobulated nucleus and a large, dark-staining cytoplasm with granules, which are characteristic features of their morphology.*
**Clinical Pearl / High-Yield Fact**
When examining a peripheral smear, it is essential to note that the presence of a bilobed nucleus in neutrophils can be a normal variant, but it can also be a sign of a underlying condition such as chronic myeloid leukemia or other myeloproliferative disorders. Therefore, it is crucial to consider the patient's clinical history and other laboratory findings when interpreting the results of a peripheral smear examination.
**Correct Answer: D.**