Isoniazid induced peripheral neuropathy responds to administrations of-
**Core Concept**
Isoniazid-induced peripheral neuropathy is a well-known side effect of isoniazid, a first-line antitubercular medication. This condition occurs due to the depletion of pyridoxine (vitamin B6) levels, which is essential for the synthesis of neurotransmitters in the nervous system.
**Why the Correct Answer is Right**
The administration of pyridoxine (vitamin B6) helps to alleviate isoniazid-induced peripheral neuropathy by replenishing the depleted stores and restoring the synthesis of neurotransmitters. Pyridoxine plays a crucial role in the synthesis of neurotransmitters such as serotonin, dopamine, and norepinephrine, which are essential for proper neuronal function.
**Why Each Wrong Option is Incorrect**
**Option A:** Thiamine (vitamin B1) is not directly related to the pathogenesis of isoniazid-induced peripheral neuropathy, although it is essential for other neurological conditions like Wernicke-Korsakoff syndrome.
**Option B:** Folic acid is important for the synthesis of nucleic acids and red blood cells but is not directly involved in the treatment of isoniazid-induced peripheral neuropathy.
**Option C:** Vitamin C is essential for collagen synthesis and iron absorption but does not play a role in the treatment of isoniazid-induced peripheral neuropathy.
**Clinical Pearl / High-Yield Fact**
It's essential to note that isoniazid-induced peripheral neuropathy can occur even at recommended doses, making regular monitoring of liver function and baseline pyridoxine levels crucial in patients receiving isoniazid therapy.
**Correct Answer: C. Pyridoxine (Vitamin B6)**