INH induced peripheral neuropathy results from deficiency of vitamin:

**Core Concept**
Isoniazid (INH)-induced peripheral neuropathy is a well-documented side effect of this antitubercular medication. This condition arises due to a deficiency of a crucial vitamin that plays a vital role in the maintenance of the nervous system.

**Why the Correct Answer is Right**
INH-induced peripheral neuropathy is primarily caused by a deficiency of vitamin B6, also known as pyridoxine. Pyridoxine is essential for the synthesis of neurotransmitters, such as serotonin and dopamine, and for the maintenance of the myelin sheath, which surrounds nerve fibers. When INH is administered, it can interfere with the metabolism of pyridoxine, leading to a deficiency. This deficiency can cause damage to the peripheral nerves, resulting in symptoms such as numbness, tingling, and weakness in the hands and feet.

**Why Each Wrong Option is Incorrect**
* **Option A:** Vitamin B12 deficiency can cause neurological symptoms, but it is not directly related to INH-induced peripheral neuropathy.
* **Option B:** Folate deficiency can cause various health problems, including anemia and neurological symptoms, but it is not the primary cause of INH-induced peripheral neuropathy.
* **Option D:** Vitamin E deficiency can cause neurological symptoms, but it is not directly related to INH-induced peripheral neuropathy.

**Clinical Pearl / High-Yield Fact**
To prevent INH-induced peripheral neuropathy, patients receiving this medication should be supplemented with pyridoxine. A dose of 10-25 mg of pyridoxine per day is usually recommended.

**Correct Answer:** A. Pyridoxine