‘PeL-Ebstein fever’ is seen in
## Core Concept
Pel-Ebstein fever is a type of recurring fever associated with **Hodgkin's lymphoma**. It is characterized by cycles of fever that can last for days to weeks, followed by afebrile periods. This condition is named after the clinicians who first described it.
## Why the Correct Answer is Right
The correct answer, **Hodgkin's lymphoma**, is associated with Pel-Ebstein fever due to the disease's impact on the body's immune response. Hodgkin's lymphoma is a type of cancer that affects the immune system, specifically the lymphatic system. The fever is thought to result from the release of **pyrogens** (substances that induce fever) by the lymphoma cells or by the body's immune response to the tumor.
## Why Each Wrong Option is Incorrect
* **Option A:** This option is incorrect because it does not correspond to a condition known to be associated with Pel-Ebstein fever.
* **Option B:** Similarly, this option does not relate to Pel-Ebstein fever.
* **Option C:** This is also not related to Pel-Ebstein fever.
## Clinical Pearl / High-Yield Fact
A key point to remember is that Pel-Ebstein fever, while suggestive of Hodgkin's lymphoma, is not pathognomonic and can be seen in other conditions. However, its association with night sweats, weight loss, and lymphadenopathy (often in a painless manner) makes Hodgkin's lymphoma a critical differential diagnosis. A classic clinical correlation is that patients with Hodgkin's lymphoma may present with **B symptoms**, which include unexplained weight loss, night sweats, and fever.
## Correct Answer: D. Hodgkin's lymphoma