Pathological findings of Sjogren’s syndrome include all except:
Correct Answer: Salivary gland germinal center lymphocyte deficient
Description: (D) Salivary gland germinal center lymphocyte deficient # Sjogren Syndrome is a clinicopathologic entity characterized by dry eyes (keratoconjunctivitis sicca) and dry mouth (xerostomia), resulting from immune-mediated destruction of the lacrimal and salivary glands.> It occurs as an isolated disorder (primary form), also known as the sicca syndrome, or more often in association with another autoimmune disease (secondary form).> Lacrimal and salivary glands are the primary targets, but other secretory glands, including those in the nasopharynx, upper airway, and vagina, may also be involved.> Involved tissues show an intense lymphocyte (primarily activated CD4+ T cells) and plasma-cell infiltrate, occasionally forming lymphoid follicles with germinal centers.> Renal involvement includes interstitial nephritis clinically manifested by hyposthenuria and renal tubular dysfunction with/without acidosis.
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