Which of the following organism plays an impoant role in pathogenesis of ‘malt worker’s lung’?
**Core Concept**
Malt worker's lung is a type of occupational hypersensitivity pneumonitis caused by the inhalation of spores from a specific organism. This condition is characterized by an exaggerated immune response to the inhaled antigen, leading to inflammation and damage in the lungs.
**Why the Correct Answer is Right**
The correct answer is **Aspergillus clavatus**. This organism produces spores that are commonly found in malted barley, leading to an allergic reaction in individuals who inhale them. The spores of A. clavatus are recognized by the immune system as foreign, triggering a release of cytokines and chemokines that attract inflammatory cells to the lungs. The resulting inflammation can cause symptoms such as shortness of breath, chest tightness, and cough.
**Why Each Wrong Option is Incorrect**
**Option A:** *Histoplasma capsulatum* is a fungus that causes histoplasmosis, a different type of lung infection. While it can cause respiratory symptoms, it is not associated with malt worker's lung.
**Option B:** *Cryptococcus neoformans* is a fungus that can cause cryptococcosis, particularly in immunocompromised individuals. It is not related to malt worker's lung.
**Option C:** *Aspergillus fumigatus* is a common mold that can cause aspergillosis, but it is not specifically linked to malt worker's lung.
**Clinical Pearl / High-Yield Fact**
Malt worker's lung is a classic example of an occupational lung disease caused by an allergic response to an inhaled antigen. It highlights the importance of recognizing the specific exposures and occupations that can lead to hypersensitivity pneumonitis.
**Correct Answer:** C. Aspergillus clavatus