**Core Concept**
Post-menopausal women undergo significant hormonal and physiological changes due to the decline in estrogen levels. This decrease affects various body systems, leading to alterations in several parameters.

**Why the Correct Answer is Right**
Estrogen has a protective effect on bone density by promoting osteoblastic activity and suppressing osteoclastic activity. With the decline in estrogen levels during menopause, bone resorption increases, leading to a decrease in bone density. Therefore, bone density is expected to decrease in post-menopausal women, not increase.

**Why Each Wrong Option is Incorrect**
* **Option A:** This option is not provided. Please provide the options to proceed with the explanation.
* **Option B:** This option is not provided. Please provide the options to proceed with the explanation.
* **Option C:** This option is not provided. Please provide the options to proceed with the explanation.
* **Option D:** This option is not provided. Please provide the options to proceed with the explanation.

**Clinical Pearl / High-Yield Fact**
Post-menopausal women are at an increased risk of osteoporosis, which can lead to fractures, particularly of the hip, spine, and wrist. Regular bone density scans and calcium/vitamin D supplementation can help prevent or manage osteoporosis.

**Correct Answer:**