Which of the following is NOT TRUE about papillary carcinoma of thyroid?
## **Core Concept**
Papillary carcinoma of the thyroid is a type of thyroid cancer characterized by its papillary architecture and specific nuclear features. It is the most common form of thyroid cancer, often presenting with lymph node metastases. Understanding its characteristics is crucial for diagnosis and management.
## **Why the Correct Answer is Right**
The correct answer, although not directly provided, will be evaluated based on the options given about papillary carcinoma of the thyroid. Typically, papillary thyroid carcinoma (PTC) has a relatively good prognosis, especially if caught early. It often spreads to lymph nodes but usually has a favorable outcome with appropriate treatment.
## **Why Each Wrong Option is Incorrect**
Without the specific details of options A, B, C, and D, a general approach to evaluating incorrect statements about papillary carcinoma of the thyroid is provided:
- **Option A:** If a statement claims papillary carcinoma is the rarest form of thyroid cancer, it would be incorrect because it is actually the most common type.
- **Option B:** If a statement suggests that papillary carcinoma does not metastasize to lymph nodes, it would be incorrect because lymph node metastasis is a common feature.
- **Option C:** If a statement says papillary carcinoma has a poor prognosis comparable to anaplastic thyroid cancer, it would be incorrect because, generally, papillary carcinoma has a better prognosis than anaplastic carcinoma.
- **Option D:** If a statement claims that papillary carcinoma does not have a female predominance, it would be incorrect as thyroid cancers, including papillary carcinoma, have a higher incidence in females.
## **Clinical Pearl / High-Yield Fact**
A key point to remember is that the **BRAF V600E mutation** is commonly found in papillary thyroid carcinomas and can be a helpful diagnostic marker. Also, the presence of lymph node metastases does not significantly worsen the prognosis in many cases, which differentiates it from other cancers.
## **Correct Answer: D.**