Gynaecology & Obstetrics . Pap smear of Lelawati 45 years female shows CIN grade III. Which of the following is the next step in management: A Punch biopsy B Large loop excision C Colposcopy directed biopsy D Cone biopsy 💡 Explanation . Pap smear of Lelawati 45 years female shows CIN grade III. Which of the following is the next step in management: ✓ Correct Answer: C. Colposcopy directed biopsy